A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.

ROMK (Kir1.1) channels are important for K secretion and recycling in the collecting duct, connecting tubule and thick ascending limb of the mammalian nephron. We have identified a highly conserved Arg in the P loop of the channel near the selectivity filter that controls Rb/K selectivity. Mutation of this Arg to a Tyr (R128Y-Kir1.1b, R147Y-Kir1.1a) increased the macroscopic conductance ratio, ...

متن کامل

A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter.

Glutamate transporters located in the brain maintain low synaptic concentrations of the neurotransmitter by coupling its flux to that of sodium and other cations. In the binding pocket of the archeal homologue Glt(Ph), a conserved methionine residue has been implicated in the binding of the benzyl moiety of the nontransportable substrate analogue threo-beta-benzyloxyaspartate. To determine whet...

متن کامل

The aromatic/arginine selectivity filter of NIP aquaporins plays a critical role in substrate selectivity for silicon, boron, and arsenic

Nodulin-26-like intrinsic proteins (NIPs) of the aquaporin family are involved in the transport of diverse solutes, but the mechanisms controlling the selectivity of transport substrates are poorly understood. The purpose of this study was to investigate how the aromatic/arginine (ar/R) selectivity filter influences the substrate selectivity of two NIP aquaporins; the silicic acid (Si) transpor...

متن کامل

Near-Optimal Controls of a Fuel Cell Coupled with Reformer using Singular Perturbation methods

A singularly perturbed model is proposed for a system comprised of a PEM Fuel Cell(PEM-FC) with Natural Gas Hydrogen Reformer (NG-HR). This eighteenth order system is decomposedinto slow and fast lower order subsystems using singular perturbation techniques that provides tools forseparation and order reduction. Then, three different types of controllers, namely an optimal full-order,a near-opti...

متن کامل

a structural survey of the polish posters

تصویرسازی قابلیتهای فراوانی را دارا است

15 صفحه اول

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Channels

سال: 2010

ISSN: 1933-6950,1933-6969

DOI: 10.4161/chan.4.3.11982