A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity
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چکیده
منابع مشابه
A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.
ROMK (Kir1.1) channels are important for K secretion and recycling in the collecting duct, connecting tubule and thick ascending limb of the mammalian nephron. We have identified a highly conserved Arg in the P loop of the channel near the selectivity filter that controls Rb/K selectivity. Mutation of this Arg to a Tyr (R128Y-Kir1.1b, R147Y-Kir1.1a) increased the macroscopic conductance ratio, ...
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ژورنال
عنوان ژورنال: Channels
سال: 2010
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.4.3.11982